Thinking Like a Phage: The Genius of the Viruses That Infect Bacteria and Archaea by Merry Youle and illustrated by Leah Pantéa

Synopsis: It isn’t easy to be a phage. First, what is a phage? A phage is a virus that infects Bacteria. To succeed, a phage must encounter, recognize, and enter a particular type of bacterial cell, then coerce it to make more phages rather than more cells. Of course, the cell resists this hostile takeover in numerous ways, all of which the successful phage overcomes. The triumphant phage then proceeds with its replicative business. In this engaging book, Merry Youle relates some of the tactics used by 21 pheatured phages to outwit their host and successfully maintain their own lineage generation after generation.

This ongoing contest of wits is a matter of life and death for both players. A phage chromosome arriving in its intended host cell is met by the cell’s state-of-the-art defenses. Unless it dodges or neutralizes every one, it will be chopped into a nutritious snack for the cell. If the phage survives, it then quickly diverts the cell’s machinery to production of more phages, rather than more cells. Under skillful phage supervision, manufacture of phage components proceeds at top speed, with all parts produced when needed and in the quantities required. As the pieces come off the assembly line, they self-assemble into sophisticated transport packages, each carrying a phage chromosome and capable of delivering it into a new host cell. When a new crop of progeny is ready - perhaps 25, 100, or more of them - the phage ruptures the cell to free them all and send them out into the world in quest of hosts of their own. Overall, a balance is maintained so that both the phages and their hosts thrive.

Many phages have the option to instead follow a different script. When they arrive in a host, they can opt to delay immediate hostile takeover and to instead form a coalition with the host for mutual benefit. In this case, as the cell grows and divides, the phage is replicated and inherited by both daughter cells. This can continue for many generations. However, if the cell encounters life-threatening difficulties, the phage ends the alliance and switches to rapid replication. Cell rupture and release of the new generation follows quickly.

Each step of the way presents challenges that test the ingenuity of the phages. In this book, tales of phage prowess are accompanied by pertinent electron micrographs; every chapter is enlivened by informative illustrations created by San Diego fine artist Leah Pantéa. The writing focuses on strategies and underlying principles, with a minimum of jargon. Since some knowledge of molecular biology is required to appreciate phage wizardry, a primer of the needed basics is provided for those unfamiliar with that subject. Thus, these phage adventures can be enjoyed by a wide audience.

Despite being the most abundant life form, the phages - being much smaller than even the microbes they infect - elude our everyday perception. Thinking Like a Phage offers a tour of this unseen dimension of life on Earth. Whether you are an expert or new to the phage world, these vignettes drawn from phage life will intrigue you. Awareness of this vast, creative, yet invisible realm can enrich your appreciation for the living world of which we, as Homo sapiens, are only a small part.

Published: May 2017 | ISBN: 978-0990494317

Book’s Homepage: https://thinkinglikeaphage.com

Mini-bio: Merry Youle is coauthor of two previous books – Life in Our Phage World and Coral Reefs in the Microbial Seas – and of more than a dozen research papers, many of which featured the phages.

Mini-bio: Leah Pantéa is a classically trained artist who earned her BFA at Central Washington University and now specializes in drawing and painting. Her current mixed media abstract landscape work draws inspiration from the Abstract Expressionist movement.

“Thinking Like a Phage is an engaging book that has the reader imagining what it is like to be a bacteriophage and to encounter the various challenges it faces, be it an obstinate cell wall, CRISPR fortifications, or a multitude of eager phage competitors.” – Graham F. Hatfull, HHMI Professor, University of Pittsburgh

“Chapter 1 is the best introduction to bacteriophage biology I have seen yet – hits all of my favorite topics! My students will enjoy reading scientific information that is presented in such a clear, interesting and exciting manner.” – Sally Molloy, Assistant Professor, University of Maine

 “a joyful book…the text framed with art…offers the phage story to the entire biology-oriented public in an easily readable way. Very good for new comers and those who do not remember anymore.” – Dennis Bamford, Professor Emeritus, University of Helsinki

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Paperback Edition: Thinking Like a Phage: The Genius of the Viruses That Infect Bacteria and Archaea
Kindle Edition: Thinking Like a Phage: The Genius of the Viruses That Infect Bacteria and Archaea