The following list is based on sales of science books in the US, as of December 2014.

1. What If?: Serious Scientific Answers to Absurd Hypothetical Questions by Randall Munroe

From the creator of the wildly popular webcomic xkcd, hilarious and informative answers to important questions you probably never thought to ask. Millions of people visit xkcd.com each week to read Randall Munroe’s iconic webcomic. His stick-figure drawings about science, technology, language, and love have a large and passionate following. Fans of xkcd ask Munroe a lot of strange questions. What if you tried to hit a baseball pitched at 90 percent the speed of light? How fast can you hit a speed bump while driving and live? If there was a robot apocalypse, how long would humanity last? In pursuit of answers, Munroe runs computer simulations, pores over stacks of declassified military research memos, solves differential equations, and consults with nuclear reactor operators. His responses are masterpieces of clarity and hilarity, complemented by signature xkcd comics. They often predict the complete annihilation of humankind, or at least a really big explosion. The book features new and never-before-answered questions, along with updated and expanded versions of the most popular answers from the xkcd website. What If? will be required reading for xkcd fans and anyone who loves to ponder the hypothetical.

2. Being Mortal: Medicine and What Matters in the End by Atul Gawande

In Being Mortal, bestselling author Atul Gawande tackles the hardest challenge of his profession: how medicine can not only improve life but also the process of its ending. Medicine has triumphed in modern times, transforming birth, injury, and infectious disease from harrowing to manageable. But in the inevitable condition of aging and death, the goals of medicine seem too frequently to run counter to the interest of the human spirit. Nursing homes, preoccupied with safety, pin patients into railed beds and wheelchairs. Hospitals isolate the dying, checking for vital signs long after the goals of cure have become moot. Doctors, committed to extending life, continue to carry out devastating procedures that in the end extend suffering. Gawande, a practicing surgeon, addresses his profession’s ultimate limitation, arguing that quality of life is the desired goal for patients and families. Gawande offers examples of freer, more socially fulfilling models for assisting the infirm and dependent elderly, and he explores the varieties of hospice care to demonstrate that a person’s last weeks or months may be rich and dignified. Full of eye-opening research and riveting storytelling, Being Mortal asserts that medicine can comfort and enhance our experience even to the end, providing not only a good life but also a good end.

3. The Innovators: How a Group of Hackers, Geniuses, and Geeks Created the Digital Revolution by Walter Isaacson

Following his blockbuster biography of Steve Jobs, The Innovators is Walter Isaacson’s revealing story of the people who created the computer and the Internet. It is destined to be the standard history of the digital revolution and an indispensable guide to how innovation really happens. What were the talents that allowed certain inventors and entrepreneurs to turn their visionary ideas into disruptive realities? What led to their creative leaps? Why did some succeed and others fail? In his masterly saga, Isaacson begins with Ada Lovelace, Lord Byron’s daughter, who pioneered computer programming in the 1840s. He explores the fascinating personalities that created our current digital revolution, such as Vannevar Bush, Alan Turing, John von Neumann, J.C.R. Licklider, Doug Engelbart, Robert Noyce, Bill Gates, Steve Wozniak, Steve Jobs, Tim Berners-Lee, and Larry Page.

4. In the Kingdom of Ice: The Grand and Terrible Polar Voyage of the USS Jeannette by Hampton Sides

In the late nineteenth century, people were obsessed by one of the last unmapped areas of the globe: the North Pole. No one knew what existed beyond the fortress of ice rimming the northern oceans, although theories abounded. The foremost cartographer in the world, a German named August Petermann, believed that warm currents sustained a verdant island at the top of the world. National glory would fall to whoever could plant his flag upon its shores. James Gordon Bennett, the eccentric and stupendously wealthy owner of The New York Herald, had recently captured the world’s attention by dispatching Stanley to Africa to find Dr. Livingstone. Now he was keen to re-create that sensation on an even more epic scale. So he funded an official U.S. naval expedition to reach the Pole, choosing as its captain a young officer named George Washington De Long, who had gained fame for a rescue operation off the coast of Greenland. De Long led a team of 32 men deep into uncharted Arctic waters, carrying the aspirations of a young country burning to become a world power. On July 8, 1879, the USS Jeannette set sail from San Francisco to cheering crowds in the grip of “Arctic Fever.” The ship sailed into uncharted seas, but soon was trapped in pack ice. Two years into the harrowing voyage, the hull was breached. Amid the rush of water and the shrieks of breaking wooden boards, the crew abandoned the ship. Less than an hour later, the Jeannette sank to the bottom,and the men found themselves marooned a thousand miles north of Siberia with only the barest supplies. Thus began their long march across the endless ice—a frozen hell in the most lonesome corner of the world. Facing everything from snow blindness and polar bears to ferocious storms and frosty labyrinths, the expedition battled madness and starvation as they desperately strove for survival. With twists and turns worthy of a thriller, In The Kingdom of Ice is a spellbinding tale of heroism and determination in the most unforgiving territory on Earth.

5. A Brief History of Time by Stephen Hawking

A landmark volume in science writing by one of the great minds of our time, Stephen Hawking’s book explores such profound questions as: How did the universe begin—and what made its start possible? Does time always flow forward? Is the universe unending—or are there boundaries? Are there other dimensions in space? What will happen when it all ends? Told in language we all can understand, A Brief History of Time plunges into the exotic realms of black holes and quarks, of antimatter and “arrows of time,” of the big bang and a bigger God—where the possibilities are wondrous and unexpected. With exciting images and profound imagination, Stephen Hawking brings us closer to the ultimate secrets at the very heart of creation.

6. Quiet: The Power of Introverts in a World That Can’t Stop Talking by Susan Cain

The book that started the Quiet Revolution. At least one-third of the people we know are introverts. They are the ones who prefer listening to speaking; who innovate and create but dislike self-promotion; who favor working on their own over working in teams. It is to introverts—Rosa Parks, Chopin, Dr. Seuss, Steve Wozniak—that we owe many of the great contributions to society. In Quiet, Susan Cain argues that we dramatically undervalue introverts and shows how much we lose in doing so. She charts the rise of the Extrovert Ideal throughout the twentieth century and explores how deeply it has come to permeate our culture. She also introduces us to successful introverts—from a witty, high-octane public speaker who recharges in solitude after his talks, to a record-breaking salesman who quietly taps into the power of questions. Passionately argued, superbly researched, and filled with indelible stories of real people, Quiet has the power to permanently change how we see introverts and, equally important, how they see themselves.

7. Thinking Fast, and Slow by Daniel Kahneman

In the international bestseller, Thinking, Fast and Slow, Daniel Kahneman, the renowned psychologist and winner of the Nobel Prize in Economics, takes us on a groundbreaking tour of the mind and explains the two systems that drive the way we think. System 1 is fast, intuitive, and emotional; System 2 is slower, more deliberative, and more logical. The impact of overconfidence on corporate strategies, the difficulties of predicting what will make us happy in the future, the profound effect of cognitive biases on everything from playing the stock market to planning our next vacation—each of these can be understood only by knowing how the two systems shape our judgments and decisions. Engaging the reader in a lively conversation about how we think, Kahneman reveals where we can and cannot trust our intuitions and how we can tap into the benefits of slow thinking. He offers practical and enlightening insights into how choices are made in both our business and our personal lives—and how we can use different techniques to guard against the mental glitches that often get us into trouble. Winner of the National Academy of Sciences Best Book Award and the Los Angeles Times Book Prize and selected by The New York Times Book Review as one of the ten best books of 2011, Thinking, Fast and Slow is destined to be a classic.

8. The Power of Habit: Why We Do What We Do in Life and Business by Charles Duhigg

In The Power of Habit, Pulitzer Prize–winning business reporter Charles Duhigg takes us to the thrilling edge of scientific discoveries that explain why habits exist and how they can be changed. Distilling vast amounts of information into engrossing narratives that take us from the boardrooms of Procter & Gamble to sidelines of the NFL to the front lines of the civil rights movement, Duhigg presents a whole new understanding of human nature and its potential. At its core, The Power of Habit contains an exhilarating argument: The key to exercising regularly, losing weight, being more productive, and achieving success is understanding how habits work. As Duhigg shows, by harnessing this new science, we can transform our businesses, our communities, and our lives.

9. How We Got to Now: Six Innovations That Made the Modern World by Steven Johnson

In this illustrated history, Steven Johnson explores the history of innovation over centuries, tracing facets of modern life (refrigeration, clocks, and eyeglass lenses, to name a few) from their creation by hobbyists, amateurs, and entrepreneurs to their unintended historical consequences. Filled with surprising stories of accidental genius and brilliant mistakes—from the French publisher who invented the phonograph before Edison but forgot to include playback, to the Hollywood movie star who helped invent the technology behind Wi-Fi and Bluetooth—How We Got to Now investigates the secret history behind the everyday objects of contemporary life. In his trademark style, Johnson examines unexpected connections between seemingly unrelated fields: how the invention of air-conditioning enabled the largest migration of human beings in the history of the species—to cities such as Dubai or Phoenix, which would otherwise be virtually uninhabitable; how pendulum clocks helped trigger the industrial revolution; and how clean water made it possible to manufacture computer chips. Accompanied by a major six-part television series on PBS, How We Got to Now is the story of collaborative networks building the modern world, written in the provocative, informative, and engaging style that has earned Johnson fans around the globe.

10. Undeniable: Evolution and the Science of Creation by Bill Nye

Sparked by a controversial debate in February 2014, Bill Nye has set off on an energetic campaign to spread awareness of evolution and the powerful way it shapes our lives. In Undeniable: Evolution and the Science of Creation, he explains why race does not really exist; evaluates the true promise and peril of genetically modified food; reveals how new species are born, in a dog kennel and in a London subway; takes a stroll through 4.5 billion years of time; and explores the new search for alien life, including aliens right here on Earth. With infectious enthusiasm, Bill Nye shows that evolution is much more than a rebuttal to creationism; it is an essential way to understand how nature works—and to change the world. It might also help you get a date on a Saturday night.

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This list has been adapted from the New York Times Best Sellers.